Condition / Intervention Kidney (renal cell) Cancer
Title Record 4
Study # CRAD001L2404
Purpose An open label, multi-center, phase II study to examine the effacacy and safety of everolimus as second line therapy in the treatment of patients with metastatic renal cell carcinoma.
click here why do husband cheat read here
Investigator Neal A Fischbach MD
Contact Information For more information about this study and to inquire about eligibility, 203-384-3611
Contact Us Use this form to email us
More Information View this trial on

Inclusion Criteria:

  • Advanced renal cell carcinoma of a histological or cytological confirmation of clear cell (or with a component of clear cell) renal carcinoma that have previously progressed on or were intolerant to first-line therapy with sunitinib, sorafenib, pazopanib, axitinib, bevacizumab, or cytokine therapy.
  • Prior nephrectomy (partial or total)
  • Patients with at least one measurable lesion at baseline as per the RECIST 1.0 criteria
  • Karnofsky Performance Status ≥ 70%

Exclusion Criteria:

  • Patients who have received more than one prior treatment regimen for metastatic renal-cell carcinoma
  • Patients who have received adjuvant therapy for RCC
  • Patients who have previously received systemic mTOR inhibitors (eg, sirolimus, temsirolimus, everolimus)
  • Patients with brain metastases
  • Patients within 4 weeks post-major surgery, open biopsy, or significant traumatic injury to avoid wound healing complications.
  • Patients who had radiation therapy within 4 weeks prior to start of study treatment (palliative radiotherapy to bone lesions allowed up to 2 weeks prior to study treatment start).
  • Concurrent severe and/or uncontrolled medical conditions (e.g., uncontrolled diabetes, active or uncontrolled infection) that could cause unacceptable safety risks or compromise compliance with the protocol

Other protocol-defined inclusion/exclusion criteria may apply

dating for married redirect unfaithful spouse
venereal disease syphilis symptoms and treatment early symptoms of hiv infection